Differential regulation of thyrotropin-releasing hormone mRNA expression in the paraventricular nucleus and dorsomedial hypothalamus in OLETF rats
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منابع مشابه
Effect of lactation on the expression of gonadotropin-inhibitory hormone in dorsomedial and paraventricular nuclei of the rat hypothalamus
Introduction: Gonadotropin inhibitory hormone (GnIH) is believed to be an inhibitor of gonadotropin releasing hormone (GnRH) secretion. The role of GnIH in lactational inhibition of gonadotropin secretion is not well known therefore, the aim of the present study was to evaluate the effect of lactation on expression of GnIH in these nuclei of lactating and non-lactating rats. Methods: Ten po...
متن کاملExpression of RFamide-related peptide in the dorsomedial nucleus of hypothalamus during the estrous cycle of rats
Introduction: RFamide-related peptide (RFRP) is believed to act as an inhibitor of gonadotropin releasing hormone (GnRH) secretion. The aim of the present study was to compare the expression pattern of RFRP neurons in the dorsomedial nucleus of hypothalamus (DMH) at different phases of the rat estrous cycle. Methods: The phases of the estrous cycle were determined in 16 adult female Sprague-...
متن کاملGlutamatergic innervation of corticotropin-releasing hormone- and thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat.
Glutamate plays a role in the central regulation of the hypothalamic-pituitary-adrenal (HPA) and thyroid (HPT) axes. Until the recent discovery of vesicular glutamate transporters (VGLUT1-3), there was no specific tool for the examination of the putative morphological relationship between the glutamatergic and the hypophysiotropic systems. Using antisera against VGLUT2, corticotropin-releasing ...
متن کاملNorepinephrine attenuates hypoxia-inhibited thyrotropin-releasing hormone release in median eminence and paraventricular nucleus of rat hypothalamus.
OBJECTIVE We have previously found that chronic hypoxia inhibited thyrotropin-releasing hormone (TRH) mRNA expression in rat paraventricular nucleus (PVN). This study presented the effects of hypoxia on TRH secretion in rat hypothalamus, and the norepinephrine (NE) involvement in the modulation of TRH secretion during acute hypoxia exposure. SETTING AND DESIGN Hypoxia was simulated at altitud...
متن کاملThe Therapeutic Effect of Thyrotropin Releasing Hormone in Amyotrophic Sclerosis
Although the issue has not yet been fully resolved, there is reason to believe that TRI-I may have a trophic effect on the normal motoneuron and may transien tly improve the neurologic deficit in ALS. Since ALS is not a simple TRI-I deficiency disease, this improvement probably occurs via a secondary mecha -nism-possibly another neurotransmitter. It is uncertain at this time whether this effec...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2019
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2019.03.030